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Antidepressants have very little effect, Peter Gotzsche, MD
 
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Hi, this is Larry Hobbs @ FatNews.com. http://fatnews.com/ https://twitter.com/fatnews Antidepressants found to have very little effect when compared to active placebo, Peter Gotzsche, MD Antidepressants have been found to have very little effect when compared to an active placebo—a placebo which causes dry mouth so that neither the patients nor the researchers can guess who is getting the real drug—notes Prof. Peter Gøtzsche, MD. He notes that the effect of the real antidepressants—tricyclic antidepressants in these trials—found a difference of only 1.3 points on the Hamilton Depression Scale, but the smallest effect that can be perceived is 5-6 points. Note: Studies show that serotonin reuptake inhibitors SSIR’s are no more effective than tricyclic antidepressants. For example, a meta-analysis published in 2000 which compared the efficacy of these two classes of drugs concluded that “There is no overall difference in efficacy between SSRIs and TCAs [tricyclic antidepressants such as amitriptiline].” Dr. Gøtzsche also notes that other antidepressant studies have found that it only takes a few days longer for the placebo group to improve by 1.3 points on the Hamilton Depression Scale which is simply the spontaneous remission of the disease. In other words, antidepressants have very little effect and most of the improvement that people experience over time is simply the natural, spontaneous remission of the depression. Antidepressants improve depression scores by only 1.3 points “A Cochrane review of tricyclic antidepressants included only trials that had atropine in the placebo to prevent unblinding because of the conspicuous side effects of the drugs. [Atropine causes dry mouth as do tricyclic antidepressants. This was done so that the patients and the researchers could not guess who was on the drug.] “This review did not find any meaningful effect; the effect corresponded to only 1.3 points on the Hamilton scale, and the smallest effect that can be perceived is 5-6 points,” writes Dr. Gøtzsche. “A meta-analysis of trials of fluoxetine [Prozac] and venlafaxine [Effexor] in severe depression showed that it takes only a few days longer before the Hamilton score in the placebo group drops by an additional 1.3 points. Thus, if we wait a few days, we would get the same result if taking a placebo, or if the patients weren’t treated at all, because what we see in a placebo group is not a placebo effect but mainly the spontaneous remission of the disease. The modest observed effect of antidepressants on anxiety can also be explained by unblinding bias because it is similar to that reported for depression.” Dr. Gøtzsche is the author of several wonderful books including Deadly Psychiatry and Organised Denial in which he talks about the problems with psychiatric drugs. He is also author of the wonderful book Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare. Dr. Gøtzsche also cofounded the Cochrane Collaboration in 1993, which is a group of scientists around the world who analyze data to try and figure out the truth about drugs and other health topics. Gotzsche PC, Young AH, and Crace J. Does long term use of psychiatric drugs cause more harm than good? BMJ, 2015 May 12; 350: h2435. The paper is available for free here: http://www.ncbi.nlm.nih.gov/pubmed/25985333 Peter C. Gøtzsche, MD pcg@cochrane.dk A list of these drugs include: Citalopram Celexa Escitalopram Lexapro, Cipralex Paroxetine Paxil, Seroxat Fluoxetine Prozac Fluvoxamine Luvox Sertraline Zoloft, Lustral Effexor XR Pristiq desvenlafaxine Cymbalta duloxetine Savella milnacipran Effexor venlafaxine Fetzima levomilnacipran Khedezla desvenlafaxine Vortioxetine Brintellix Levomilnacipran SNRI Fetzima Vilazodone SSRI Viibryd Citalopram Celexa Escitalopram Lexapro, Cipralex Fluoxetine Prozac, Sarafem; Pexeva Fluvoxamine Luvox Paroxetine Paxil, Paxil CR Sertraline Zoloft Desvenlafaxine Pristiq Duloxetine Cymbalta Levomilnacipran Fetzima Milnacipran Savella Venlafaxine Effexor, Effexor XR Mirtazapine Remeron, Remeron SolTab Bupropion Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban; Aplenzin Atomoxetine Norepinephrine reuptake Inhibitor Strattera Agomelatine 5-HT2C receptor antagonist Valdoxan Buspirone 5HT1A receptor agonist Buspar Nefazodone 5HT2-receptor antagonist Nefadar, Serzone Tandospirone azapirone, 5HT1A receptor agonist Sediel Tianeptine Serotonin reuptake enhancer Stablon Trazodone 5HT2-receptor antagonist, triazolopyridine-derivative Desyrel, Apo-Trazodone, Oleptro Reboxetine Norepinephrine Reuptake Inhibitor Edronax, Vestra Viloxazine NRI Vivalan Vilazodone Selective serotonin reuptake inhibitor, Serotonin 5HT 1A receptor agonist Viibryd Serotonin Modulator and Stimulator Vortioxetine Brintellix Combinations Fluoxetine/Olanzapine SSRI/antipsychotic Symbyax Amitriptyline/Perphenazine TCA/antipsychotic Etrafon, Triavil
Views: 521 Fatnews
Drug studies exaggerate benefits of psychiatric drugs, Peter Gotzsche, MD
 
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Hi, this is Larry Hobbs @ FatNews.com. http://fatnews.com/ https://twitter.com/fatnews Psychiatric drug studies exaggerate benefits of these drugs by study design says Peter Gotzsche, MD “The randomised trials [of psychiatric drugs] that have been conducted do not properly evaluate the drugs’ effects,” writes Prof. Peter Gøtzsche, MD. “Almost all of them are biased because they included patients already taking another psychiatric drug. “Patients, who after a short wash-out period are randomised to placebo, go “cold turkey” and often experience withdrawal symptoms. “This design exaggerates the benefits of treatment and increases the harms in the placebo group, and it has driven patients taking placebo to suicide in trials in schizophrenia. Dr. Gøtzsche is the author of several wonderful books including Deadly Psychiatry and Organised Denial in which he talks about the problems with psychiatric drugs. He is also author of the wonderful book Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare. Dr. Gøtzsche also cofounded the Cochrane Collaboration in 1993, which is a group of scientists around the world who analyze data to try and figure out the truth about drugs and other health topics. Reference Gotzsche PC, Young AH, and Crace J. Does long term use of psychiatric drugs cause more harm than good? BMJ, 2015 May 12; 350: h2435. The paper is available for free here: http://www.ncbi.nlm.nih.gov/pubmed/25985333 Peter C. Gøtzsche, MD pcg@cochrane.dk A list of these drugs include: Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Dapoxetine, Seproxetine, Mesembrine, Zimelidine, Venlafaxine, Duloxetine, Desvenlafaxine, Milnacipran, Venlafaxine Hydrochloride, Desvenlafaxine succinate, Duloxetine hydrochloride, Milnacipran hydrochloride Citalopram (Celexa) Escitalopram (Lexapro, Cipralex) Paroxetine (Paxil, Seroxat) Fluoxetine (Prozac) Fluvoxamine (Luvox) Sertraline (Zoloft, Lustral) Effexor XR Pristiq generic name: desvenlafaxine Cymbalta generic name: duloxetine Savella generic name: milnacipran Effexor generic name: venlafaxine Fetzima generic name: levomilnacipran Khedezla generic name: desvenlafaxine Vortioxetine (serotonin modulator and stimulator) Brintellix, Levomilnacipran (SNRI) Fetzima, Vilazodone (SSRI) Viibryd, SSRIs (Selective Serotonin Reuptake Inhibitors) Citalopram Celexa Escitalopram Lexapro, Cipralex Fluoxetine Prozac, Sarafem; Pexeva Fluvoxamine Luvox Paroxetine Paxil, Paxil CR Sertraline Zoloft Desvenlafaxine Pristiq Duloxetine Cymbalta Levomilnacipran Fetzima Milnacipran Savella Venlafaxine Effexor, Effexor XR Mirtazapine Remeron, Remeron SolTab Bupropion Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban; Aplenzin Atomoxetine (Norepinephrine reuptake Inhibitor) Strattera Agomelatine (5-HT2C receptor antagonist) Valdoxan Buspirone (5HT1A receptor agonist) Buspar Nefazodone (5HT2-receptor antagonist) Nefadar, Serzone Tandospirone (azapirone, 5HT1A receptor agonist) Sediel Tianeptine (Serotonin reuptake enhancer) Stablon Trazodone (5HT2-receptor antagonist, triazolopyridine-derivative) Desyrel, Apo-Trazodone, Oleptro Reboxetine (Norepinephrine Reuptake Inhibitor) Edronax, Vestra Viloxazine (NRI) Vivalan Vilazodone (Selective serotonin reuptake inhibitor, Serotonin 5HT 1A receptor agonist) Viibryd Serotonin Modulator and Stimulator Vortioxetine Brintellix Combinations Fluoxetine/Olanzapine (SSRI/antipsychotic) Symbyax Amitriptyline/Perphenazine (TCA/antipsychotic) Etrafon, Triavil Abilify (aripiprazole) amisulpride aripiprazole asenapine Camcolit (lithium carbonate) chlorprothixene chlorpromazine clopenthixol Clopixol Acuphase injection (zuclopenthixol acetate) clozapine Clozaril (clozapine) Compazine (prochlorperazine) Depixol (flupentixol) Depixol for injection (flupentixol decanoate) Eskalith (lithium carbonate) Fanapt (iloperidone) FazaClo (clozapine) Fluanxol (flupentixol) flupentixol flupentixol decanoate fluphenazine HCl tablets fluphenazine decanoate Geodon oral capsules (ziprasidone) Geodon intramuscular injection (IM) (ziprasidone mesylate) fast-acting, not long-lasting Haldol (haloperidol) Haldol for injection (haloperidol decanoate) haloperidol haloperidol decanoate iloperidone Invega (paliperidone) Invega Sustenna for injection (paliperidone palmitate) Latuda (lurasidone) lithium (lithium carbonate) Lithobid (lithium carbonate) loxapine succinate Loxitane (loxapine) lurasidone Mellaril (thioridazine HCl) mesoridazine besylate PI sheet before from before it was discontinued in the US. Moban (molindone HCl) molindone Navane (thiothixene) olanzapine olanzapine pamoate Orap (pimozide) paliperidone paliperidone palmitate perphenazine pimozide prochlorperazine Prolixin (fluphenazine HCl) Prolixin for injection (fluphenazine decanoate) quetiapine reserpine Risperdal (risperidone) risperidone Saphris (asenapine) Serdolect (sertindole) sertindole Seroquel (quetiapine) Serpasil (reserpine) thioridazine thiothixene
Views: 895 Fatnews
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