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Asthma Treatment and Medications to Prevent Exacerbations or Asthma Attacks
 
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This a review from the Journal of Allergy and Clinical Immunology. It reviews how using the correct asthma medication and using appropriate asthma treatment will prevent asthma attacks or asthma exacerbations. Using inhaled corticosteroids, long acting beta agonists and leukotriene antagonists will control asthma inflammation and eosinophils. The goal is to have great asthma control and that will result in less asthma symptoms and attacks. This will reduce the need for oral steroids, like prednisone. It will also prevent or reduce asthma emergency room visits and asthma hospitalizations.
Views: 1264 America's Allergist
Novel biomarkers in childhood asthma – Video abstract [ID 149577]
 
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Video abstract of a review paper “Severe bronchial asthma in children: a review of novel biomarkers used as predictors of disease” published in the open access Journal of Asthma and Allergy by Uwaezuoke et al. Severe asthma or therapy-resistant asthma in children is a heterogeneous disease that affects all age-groups. Given its heterogeneity, precision in diagnosis and treatment has become imperative, in order to achieve better outcomes. If one is thus able to identify specific patient phenotypes and endotypes using the appropriate biomarkers, it will assist in providing the patient with more personalized and appropriate treatment. However, there appears to be a huge diagnostic gap in severe asthma, as there is no single test yet that accurately determines disease phenotype. In this paper, we review the published literature on some of these biomarkers and their possible role in bridging this diagnostic gap. We also highlight the cellular and molecular mechanisms involved in severe asthma, in order to show the basis for the novel biomarkers. Some markers useful for monitoring therapy and assessing airway remodeling in the disease are also discussed. A review of the literature was conducted with PubMed to gather baseline data on the subject. The literature search extended to articles published within the last 40 years. Although biomarkers specific to different severe asthma phenotypes have been identified, progress in their utility remains slow, because of several disease mechanisms, the variation of biomarkers at different levels of inflammation, changes in relying on one test over time (eg, from sputum eosinophilia to blood eosinophilia), and the degree of invasive tests required to collect biomarkers, which limits their applicability in clinical settings. In conclusion, several biomarkers remain useful in recognizing various asthma phenotypes. However, due to disease heterogeneity, identification and utilization of ideal and defined biomarkers in severe asthma are still inconclusive. The development of novel serum/sputum-based biomarker panels with enhanced sensitivity and specificity may lead to prompt diagnosis of the disease in the future. Read the review paper here: https://www.dovepress.com/severe-bronchial-asthma-in-children-a-review-of-novel-biomarkers-used--peer-reviewed-article-JAA
Views: 67 Dove Medical Press
Dupilumab in the treatment of atopic dermatitis - Video Abstract ID 133661
 
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Video abstract of review “Dupilumab: an evidence-based review of its potential in the treatment of atopic dermatitis” published in the open access journal Core Evidence by Eshtiaghi P, Gooderham MJ. Introduction: Atopic dermatitis (AD) is a recurrent, pruritic inflammatory skin disease with complex immunopathogenesis characterized by a dominant TH2 response. Dupilumab is an interleukin (IL)-4 receptor alpha antagonist that subsequently blocks IL-4 and IL-13 signaling. It has recently been approved for the treatment of adult patients with moderate-to-severe AD whose current treatment options are limited. Aim: This article reviews the evidence of clinical efficacy, safety, and patient-reported outcome (PRO) measures from Phase I–III trials of dupilumab in adult patients with moderateto- severe AD. Evidence review: Results from clinical trials of dupilumab in adults with moderate-to-severe AD have shown that weekly or biweekly dupilumab injections significantly improve clinical and PROs. Transcriptome and serum analyses also found that dupilumab significantly modulates the AD molecular signature and other TH2-associated biomarkers, compared with placebo. Additionally, concomitant use of dupilumab with topical corticosteroids (TCS) results in a greater improvement in signs and symptoms of AD than with dupilumab use alone. Throughout the trials, common adverse events were headaches, conjunctivitis, and injection site reactions. These were consistently mild–moderate and occurred with similar frequency between the treatment and placebo groups. Place in therapy: In adult patients with moderate-to-severe refractory AD, monotherapy or concomitant use of dupilumab with TCS holds great promise to significantly improve clinical outcomes and quality of life of the patient. Ongoing studies of dupilumab will help determine the clinical efficacy and safety profile of its long-term use. Finally, further economic evidence is warranted to compare the long-term costs and benefits of dupilumab with other currently available treatments for moderate-to-severe AD. Read the Review paper here: https://www.dovepress.com/dupilumab-an-evidence-based-review-of-its-potential-in-the-treatment-o-peer-reviewed-article-CE
Views: 659 Dove Medical Press
Dupilumab in Persistent Asthma: Pulmonary Journal Club *
 
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G. Molina MD * Outstanding talk - received a rating from attendees of at least 4.5 out of 5.
Views: 511 Chief Fellow
Journal Club Presentation (Dr. Heba Elwan)
 
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Journal Club Presentation: ------------------------------------------------------------------------- Randomized Trial of Dexamethasone Versus Prednisone for Children with Acute Asthma Exacerbations Journal Club Presentation is part of FADIC Drug Information Program, and Workshop. Be professional, and learn how to present a journal club presentation, by registering in FADIC Drug Information Program. تعلم كيف تعرض بحث من جورنال من خلال الاشتراك في برنامج فادك للمعلومات الدوائية .. تعلم كل الأسس التي تساعدك في عرض أي بحث من جورنال تفاصيل البرنامج كاملة: https://fadic.net/en/courses/drug-information-program/
Views: 83 FADIC tube
Hot Topics in Diagnostic Microbiology  Chlamydia and Asthma
 
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While the pathogen Chlamydia pneumoniae has been linked to asthma in the past, new research finds over two-thirds of people with severe asthma test positive for Chlamydia-specific antibodies, suggesting this antigen could be a good biomarker for detecting those at risk for asthma. Additional research finds that, in some cases, antibiotic therapy could improve asthma symptoms. Eduard Drizik, University of Massachusetts, Amherst
Как собака может защитить вас еще до вашего рождения
 
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Канал Ольги: https://www.youtube.com/user/EnglishExpertsRu Наука и Техника Вконтакте: http://vk.com/science_technology Ссылка на оригинальное видео: https://www.youtube.com/watch?v=ex5y6OVVHe0 Поддержите канал: http://www.patreon.com/AlexTranslations Яндекс 41001616074670 WebMoney: R389686533481 U330507290710 Дополнительная информация: https://goo.gl/FA6uIv - Собака https://goo.gl/vIqw79 - Очистка сточных вод Источники: Arbes Jr, S. J., Gergen, P. J., Elliott, L., & Zeldin, D. C. (2005). Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. Journal of Allergy and Clinical Immunology, 116(2), 377-383. Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B. L. K., Skov, T., Paludan-Müller, G., ... & Krogfelt, K. A. (2011). Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. Journal of Allergy and Clinical Immunology, 128(3), 646-652. Fujimura, K. E., Johnson, C. C., Ownby, D. R., Cox, M. J., Brodie, E. L., Havstad, S. L., ... & Lynch, S. V. (2010). Man's best friend? The effect of pet ownership on house dust microbial communities. The Journal of allergy and clinical immunology, 126(2), 410. Gergen, P. J., Arbes Jr, S. J., Calatroni, A., Mitchell, H. E., & Zeldin, D. C. (2009). Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006. Journal of Allergy and Clinical Immunology, 124(3), 447-453. Havstad, S., Wegienka, G., Zoratti, E. M., Lynch, S. V., Boushey, H. A., Nicholas, C., ... & Johnson, C. C. (2011). Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood. Journal of Allergy and Clinical Immunology, 128(4), 880-885. Jakobsson, H. E., Abrahamsson, T. R., Jenmalm, M. C., Harris, K., Quince, C., Jernberg, C., ... & Andersson, A. F. (2013). Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section. Gut. Joseph, C. L., Ownby, D. R., Havstad, S. L., Woodcroft, K. J., Wegienka, G., MacKechnie, H., ... & Johnson, C. C. (2011). Early complementary feeding and risk of food sensitization in a birth cohort. Journal of Allergy and Clinical Immunology, 127(5), 1203-1210. McNeill, G., Tagiyeva, N., Aucott, L., Russell, G., & Helms, P. J. (2009). Changes in the prevalence of asthma, eczema and hay fever in pre‐pubertal children: a 40‐year perspective. Paediatric and perinatal epidemiology, 23(6), 506-512. Smallwood, J., & Ownby, D. (2012). Exposure to dog allergens and subsequent allergic sensitization: an updated review. Current allergy and asthma reports,12(5), 424-428.
Views: 137728 AlexTranslations
Capnography
 
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This video is intended to give an overview of capnography. The basic principles, terminology, indications and contraindications, and physics of absorption spectroscopy are discussed. There is also a brief discussion of mainstream vs side stream waveforms. In the coming videos we will get into more detail regarding various aspects of capnograpy. Please refer to these important references that were used to create this video: 1. Ortega, R., Connor, C., Kim, S., Djang, R., and Patel, K. 2012. Monitoring Ventilation with Capnography. New England Journal of Medicine 367;19 2. Capnography: Clinical Aspects. Gravestein, Jaffe and Paulus. Cambridge University Press 2004.
Views: 5891 RespiratoryReview
Asthma with bronchial hypersecrection: role of TLRs and mucins- Video Abstract ID 142200
 
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Video abstract of original research paper “Asthma with bronchial hypersecretion: expression of mucins and toll-like receptors in sputum and blood” published in the open access journal Journal of Asthma and Allergy by authors Crespo-Lessmann A, Mateus E, Torrejón M, et al. Abstract: Asthma with bronchial hypersecretion is a type of asthma that is poorly studied. Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC). Objectives: 1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without bronchial hypersecretion. Materials and methods: Cross-sectional study which included 43 non-smoking asthmatic patients without bronchiectasis, 19 with bronchiectasis, and 24 without bronchial hypersecretion. All patients underwent the following: IS, spirometry, fractional exhaled nitric oxide, prick test, total immunoglobulin E (IgE), and blood albumin. Analysis of mucins was determined by ELISA and expression of TLR2 and TLR4 by flow cytometry. The level of asthma control was determined by the Asthma Control Test (ACT) questionnaire and quality of life was assessed by the reduced version of the Asthma Quality of Life Questionnaire (mini-AQLQ). Results: Asthmatics with bronchial hypersecretion were significantly older (62.6 years vs 48.5 years; p=0.02); had greater severity (persistent severe asthma 94.7% vs 29.2%; p=0.000); a higher proportion of nasal polyposis (36.8% vs 8.3%; p=0.022); less control of asthma (73.7% vs 8.3%; p=0,000); a higher proportion of asthma with negative prick test (68.4% vs 16.6%; p=0.001), and lower levels of IgE (113.4 IU/mL vs 448 IU/mL; p=0.007), compared with asthmatics without bronchial hypersecretion. Significant differences were observed neither in the expression of TLRs 2 and 4 in inflammatory cells of IS or peripheral blood, nor in the expression of mucins between both groups. View the original paper: https://www.dovepress.com/asthma-with-bronchial-hypersecretion-expression-of-mucins-and-toll-lik-peer-reviewed-article-JAA
Views: 66 Dove Medical Press
Seeking innovative solutions for severe asthma
 
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To access this issue of Topics in Focus: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1843/homepage/seeking_innovative_solutions_for_severe_asthma.htm Seeking innovative solutions for severe asthma Series Editors: Vanessa McDonald, Peter Gibson and Steven Maltby The purpose of the series editors for this series ‘Seeking Innovative Solutions in Severe Asthma’ was to generate discussion and interest in novel and innovative severe asthma research and clinical practice. The series opens with a review reporting the outcome of a roundtable discussion on current management, targeted therapies and future directions, with each of these aspects being then covered in subsequent reviews of the series in both adults and children. The series editors are optimistic and excited to present the latest developments in the treatment of severe asthma and their potential to improve the lives of patients with this difficult disease. We hope that you will share their vision and enthusiasm through their review series. McDonald, V.M., Maltby, S. and Gibson, P.G. (2016) Severe asthma: Can we fix it?. Respirology, 22: 19–20. doi: 10.1111/resp.12956. McDonald, V.M., Maltby, S., Reddel, H.K., King, G.G., Wark, P.A.B., Smith, L., Upham, J.W., James, A.L., Marks, G.B. and Gibson, P.G. (2016) Severe asthma: Current management, targeted therapies and future directions—A roundtable report. Respirology, 22: 53–60. doi: 10.1111/resp.12957. Fricker, M., Heaney, L.G. and Upham, J.W. (2017) Can biomarkers help us hit targets in difficult-to-treat asthma?. Respirology, 22: 430–442. doi: 10.1111/resp.13014. Porsbjerg, C. and Menzies-Gow, A. (2017) Co-morbidities in severe asthma: Clinical impact and management. Respirology, 22: 651–661. doi: 10.1111/resp.13026. Maltby, S., Tay, H.L., Yang, M. and Foster, P.S. (2017) Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation. Respirology, 22: 874–885. doi: 10.1111/resp.13052. Bush, A., Fleming, L. and Saglani, S. (2017) Severe asthma in children. Respirology, 22: 886–897. doi: 10.1111/resp.13085. Clark, V.L., Gibson, P.G., Genn, G., Hiles, S.A., Pavord, I.D. and McDonald, V.M. (2017) Multidimensional assessment of severe asthma: A systematic review and meta-analysis. Respirology, 22: 1262–1275. doi: 10.1111/resp.13134. King, G.G., James, A., Harkness, L. and Wark, P.A.B. (2018) Pathophysiology of severe asthma: We’ve only just started. Respirology, 23: 262–271., doi: 10.1111/resp.13251. McDonald, V.M., Maltby, S. and Gibson, P.G. (2018) Severe asthma: We can fix it? We can try!. Respirology, 23: 260–261., doi: 10.1111/resp.13249. Music: Deliberate Thought by Kevin MacLeod is licensed under a Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) Source: http://incompetech.com/music/royalty-free/?keywords=deliberate+thought Artist: http://incompetech.com/
Views: 39 Respirology Video
Science Works! How the Scientific Peer Review Process works
 
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Dr. Kevin Padian - Professor of Integrative Biology explains the scientific peer review process and the debate between evolution vs. creation. Video from: Scientists Interviewed by Qualitative Researcher, Allison Hoffman
Views: 17715 logicalthinkingorg
How to Submit your Research to the Journal of Clinical Microbiology
 
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Submit your research papers for review at http://jcm.asm.org Alexander J. McAdam, Editor in Chief, introduces the Journal of Clinical Microbiology published by the American Society for Microbiology. The Journal of Clinical Microbiology (JCM) publishes the most current research related to the laboratory diagnosis of human and animal infections and the role of the laboratory in both the management of infectious diseases and the elucidation of the epidemiology of infections.
Study: Pet allergens in infancy lowers asthma risk
 
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CINCINNATI (WKRC) - Children exposed to high indoor levels of pet or pest allergens during infancy have a lower risk of developing asthma by age seven according to this new report. Researchers announced on Tuesday in the Journal of Allergy and Clinical Immunology that this may provide clues for the design of strategies to prevent asthma from developing. Previous studies have established that reducing allergen exposure in the home helps control asthma, this study found that exposure to certain allergens early in life, before asthma develops, may have a preventive effect. The hope is that learning new ways to prevent asthma before it develops can help reduce the odds a child will get asthma later in life. As part of this study, 560 newborns who were at high risk for developing asthma were enrolled in this study at birth. The risk was determined by family history of asthma. At least one parent had it. Those who had higher mouse, cat and even cockroach allergens in the dust in their homes in the first three years of life had lower risk for asthma by age seven. Now the same was true for dogs, but researchers say more research needs to be done to confirm this is true, because the dog numbers were not as statistically significant. So mice, cats, cockroaches and maybe dogs was the result.
Views: 50 LOCAL 12
A type of vitamin E found in nuts may prevent asthma , reveals study
 
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Sufferers had reduced airway inflammation and less sticky mucus in lungs. The form of vitamin E that brought these beneficial effects is gamma-tocopherol. This is abundant in nuts such as walnuts and pecans and in the legume peanut. It is also present in seed oils such as corn, soybean and sesame Changing one's diet or taking a supplement may help control the condition. source: http://www.dailymail.co.uk the Journal of Allergy & Clinical Immunology Article-TUBE2 is informational and learning portal for raising awareness for healthy food and wellness portal that today is a treasure of information. Daily are publishing new information in the field of nutrition, current information and educational content deployed in several thematic areas like: Natural Remedies, Diet and Weight loss, Health Benefits of Fruits and Vegetables, Healthy Recipes, Health Tips and many more. contact us www.facebook.com/misha.barca FOLLOW US ON FACEBOOK www.facebook.com/tabkhat twitter www.twitter.com/miamolosiva
Views: 1099 Article-TUBE2
Charité Clinical Journal Club by Fred Luft - 21.03.2018
 
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The N Engl J Med image of the week shows a 13-year-old boy who presented to the orthopedic clinic with a 1-week history of bilateral knee pain. He was active in sports and participated in long jump. Examination of the right knee showed mild soft-tissue swelling and tenderness over the tibial tubercle, and taut quadriceps muscle; and the exam of the left knee was normal. Plain radiographs of both knees were done. What is the likely diagnosis? You are offered Hoffa’s syndrome, patellar tendon avulsion, pes anserine bursitis, osteomyelitis of the proximal tibia, and Osgood-Schlatter’s disease. We review these conditions. Asthma exacerbations occur frequently despite the regular use of asthma-controller therapies, such as inhaled glucocorticoids. Clinicians commonly increase the doses of inhaled glucocorticoids at early signs of loss of asthma control. However, data on the safety and efficacy of this strategy in children are limited. Investigators studied 254 children, 5 to 11 years of age, who had mild-to-moderate persistent asthma and had had at least one asthma exacerbation treated with systemic glucocorticoids in the previous year. The children were randomly assigned to either continue the same dose (low-dose group) or use a quintupled dose (high-dose group; fluticasone at a dose of 220 μg per inhalation, two inhalations twice daily) for 7 days at the early signs of loss of asthma control (“yellow zone”). Treatment was provided in a double-blind fashion. The primary outcome was the rate of severe asthma exacerbations treated with systemic glucocorticoids. We learn that quintupling the dose of inhaled glucocorticoids at the early signs of loss of asthma control did not result in a lower rate of exacerbations than continuation of the daily maintenance dose, did not improve other asthma outcomes, and may be associated with diminished linear growth. Next, we inspect a very similar study in adolescents and adults with asthma. Investigators compared a self-management plan that included an increase in the dose of inhaled glucocorticoids by a factor of 4 (quadrupling group) with the same plan without such an increase (non-quadrupling group), over a period of 12 months. The primary outcome was the time to a first severe asthma exacerbation, defined as treatment with systemic glucocorticoids or an unscheduled health care consultation for asthma. A temporary quadrupling of the dose of inhaled glucocorticoids at the time of worsening asthma control resulted in a lower rate of severe exacerbations of asthma than no increase in the dose (45% vs. 52%). Pregnant women with an elevated viral load of hepatitis B virus (HBV) have a risk of transmitting infection to their infants, despite the infants’ receiving hepatitis B immune globulin. Investigators randomly assigned hepatitis B e antigen (HBeAg)–positive pregnant women with an alanine aminotransferase level of 60 IU or less per liter to receive tenofovir disoproxil fumarate (TDF) or placebo from 28 weeks of gestation to 2 months postpartum. The primary end point was a hepatitis B surface antigen (HBsAg)–positive status in the infant, confirmed by the HBV DNA level at 6 months of age. Because the rate of HBV transmission was lower than expected, the trial gave a negative result. The next investigators describe a gain-of-function variant in the EPO gene that results in familial erythrocytosis. A single nucleotide deletion in exon 2 results in a frameshift of the EPO coding sequence. The mutation confers a gain of function involving an alternative transcript that is then overexpressed. The review is on Sjögren’s syndrome. The patient of the week is a 25 year old man with seizures, sagittal sinus thrombosis, a Marfanoid habitus but he does not have Marfan’s syndrome. His homocysteine level was 365 µmol/L. In the Lancet, we inspect a pooled analysis comparing stenting to bypass surgery. CABG was better in diabetics and multiple-vessel disease in terms of survival. We inspect a randomized prospective trial of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medications...
"Asthma" by Gerhard Wolf, MD for OPENPediatrics
 
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Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu Please note: OPENPediatrics does not support nor control any related videos in the sidebar, these are placed by Youtube. We apologize for any inconvenience this may cause.
Views: 956 OPENPediatrics
Pitt/UPMC Asthma Study Finds Potential Treatment
 
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In research published online by the New England Journal of Medicine at the same May 21, 2013 time when Sally Wenzel, M.D., was presenting her findings to the annual meeting of the American Thoracic Society. Wenzel and scientists from the University of Pittsburgh School of Medicine plus other national study sites found an experimental, lab-made molecule was able to stick to certain inflammatory proteins and reduce acute breathing problems among people with a type of moderate-to-severe asthma. For more, visit: http://http://www.asthmainstitute.pitt.edu/
Views: 1452 UPMC
Study links fast food to childhood asthma
 
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Researchers have found a link between severe childhood asthma and fast food. A new study in the medical journal Thorax found that three or more weekly servings of junk food substantially increased the risk among teens and young children. The study says it could be the food's high concentrations of saturated fats which compromise the immune system of children, making them more prone to a whole range of health problems. Al Jazeera's Simon MacGregor Wood reports from London.
Views: 2192 Al Jazeera English
Tindora Fry / Ivy Gourd Fry Healthy for Asthma and Diabetes patients
 
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Tindora Fry / Ivy Gourd Fry / Dondakaya Fry Tindora Fry / Ivy Gourd Fry Healthy for Asthma and Diabetes patients Although ivy gourd is most commonly used as a natural remedy for diabetes, some people use ivy gourd for the following conditions: asthma constipation high cholesterol Ivy gourd is also purported to reduce inflammation. In addition, ivy gourd leaves are sometimes applied to skin to help promote wound healing. Benefits of Ivy Gourd To date, research on the potential health benefits of ivy gourd is very limited and dated. However, some studies suggest that ivy gourd may help fight diabetes. For instance, a 2003 research review from Diabetes Care indicates that ivy gourd may be effective in the treatment of diabetes. For the review, investigators looked at 108 trials examining a total of 36 herbs and 9 vitamin/mineral supplements for their effectiveness in the treatment of diabetes. Although the review's authors concluded that American ginseng and ivy gourd had the strongest scientific support for their efficacy, it's important to note that very few clinical trials on the use of ivy gourd for diabetes control have been published in recent years. One of the few recently published trials is a 2008 study from Diabetes Care. The study involved 60 patients with mild diabetes, each of whom took either a placebo or ivy gourd extract every day for 90 days. Study results showed that members of the ivy gourd group experienced a significantly greater improvement in blood sugar levels (compared to members of the placebo group). What's more, a small study published in the Indian Journal of Medical Sciences in 2008 found that six weeks of treatment with ivy gourd supplements helped regulate blood sugar levels in diabetes patients. The authors of the study (which involved 30 people with diabetes) suggest that ivy gourd may aid in blood sugar control by having an insulin-like effect on patients.
Views: 7061 YUMMY RECIPES
Charité Clinical Journal Club by Fred Luft - 24.8.2016
 
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The N Engl J Med image of the week shows a computer-constructed MRI transverse cranial image. The eyes are visible for orientation. A left sided temporal-frontal lesion moves the brain mass to the right. The lesion looks cystic but has a material content. You are offered: colloid cyst, glioblastoma multiforme, thrombosed intracranial aneurysm, choroid plexus metastasis, and intraventricular meningioma. We discuss and show all possibilities. Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking. In a multicenter, prospective, randomized, double-blind, parallel-group trial, investigators enrolled 300 children (age range, 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks. The primary outcome was the number of asthma exacerbations that led to treatment with systemic glucocorticoids. The results showed no significant difference in the frequency of asthma exacerbations or in asthma control between the two treatment groups. What bothered me about this study is the lack of evidence that lowering body temperature is of utility in any pediatric disease. Furthermore, I am not aware that asthma attacks are painful, albeit admittedly uncomfortable. Thus, it was not clear to me why this study needed to be done and why it was not placebo controlled. The authors stated: “We excluded a placebo group for ethical reasons, since giving placebo to a child with fever, malaise, and pain would not be acceptable.” Fever and pain seem lame arguments. I have no evidence that acetaminophen or ibuprofen have been tested for malaise. Primary biliary cholangitis (formerly called primary biliary cirrhosis) can progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase and bilirubin levels correlate with the risk of liver transplantation or death. Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefit in patients with this disease. In this 12-month, double-blind, placebo-controlled, phase 3 trial, investigators randomly assigned 217 patients who had an inadequate response to ursodiol or who found the side effects of ursodiol unacceptable to receive obeticholic acid at a dose of 10 mg (the 10-mg group), obeticholic acid at a dose of 5 mg with adjustment to 10 mg if applicable (the 5–10-mg group), or placebo. Obeticholic acid administered with ursodiol or as monotherapy for 12 months in patients with primary biliary cholangitis resulted in decreases from baseline in alkaline phosphatase and total bilirubin levels that differed significantly from the changes observed with placebo. However, there were more serious adverse events with obeticholic acid. In patients with type 1 diabetes who are not pregnant, closed-loop (automated) insulin delivery can provide better glycemic control than sensor-augmented pump therapy, but data are lacking on the efficacy, safety, and feasibility of closed-loop therapy during pregnancy. We inspect a trial showing that closed-loop beats pump alone. For more than a decade, targeted genetic testing has enhanced risk stratification for hypertrophic cardiomyopathy. Using sequencing results, clinicians routinely assess the risk of hypertrophic cardiomyopathy in a patient’s relatives and diagnose the condition in patients who have ambiguous clinical presentations. However, the benefits of genetic testing come with the risk that variants may be misclassified. We learn that minimizing misclassifications by sifting through genomic noise for causal variants is closely related to assessing penetrance and the proportion of persons with the variant who have the disease. The N Engl J Med review is on genital Herpes simplex virus. The case of the week is about a 33 year-old bisexual man who develops anal pain and bloody stools. It took these guys 3 months to work this up! FInd more in the lecture.
Listen to Wisia Wedzicha discuss the ATS journals and how to submit papers
 
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At the European Respiratory Society International Congress this year, AJRCCM editor in chief Jadwiga "Wisia" Wedzicha, MD, gave a presentation on the Blue Journal. Watch the full session here.
How Your Dog Can Protect You Before You're Born
 
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Please support MinuteEarth on Patreon!: https://goo.gl/ZVgLQZ And subscribe! http://goo.gl/EpIDGd Thanks to all our Patreon supporters, who help make MinuteEarth possible, especially: Michael Hawkins (from Subbable) Murray Down (from Subbable) Herein we explain how pets can help your immune system, beginning when you're in utero! Created by Henry Reich Animation: Ever Salazar Production and Writing Team: Alex Reich, Peter Reich, Emily Elert Music: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder MinuteEarth is available as a free iTunes podcast! - https://goo.gl/sfwS6n Facebook - http://facebook.com/minuteearth Twitter - http://twitter.com/MinuteEarth MinuteEarth provides an energetic and entertaining view of trends in earth's environment -- in just a few minutes! References Arbes Jr, S. J., Gergen, P. J., Elliott, L., & Zeldin, D. C. (2005). Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. Journal of Allergy and Clinical Immunology, 116(2), 377-383. Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B. L. K., Skov, T., Paludan-Müller, G., ... & Krogfelt, K. A. (2011). Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. Journal of Allergy and Clinical Immunology, 128(3), 646-652. Fujimura, K. E., Johnson, C. C., Ownby, D. R., Cox, M. J., Brodie, E. L., Havstad, S. L., ... & Lynch, S. V. (2010). Man's best friend? The effect of pet ownership on house dust microbial communities. The Journal of allergy and clinical immunology, 126(2), 410. Gergen, P. J., Arbes Jr, S. J., Calatroni, A., Mitchell, H. E., & Zeldin, D. C. (2009). Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006. Journal of Allergy and Clinical Immunology, 124(3), 447-453. Havstad, S., Wegienka, G., Zoratti, E. M., Lynch, S. V., Boushey, H. A., Nicholas, C., ... & Johnson, C. C. (2011). Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood. Journal of Allergy and Clinical Immunology, 128(4), 880-885. Jakobsson, H. E., Abrahamsson, T. R., Jenmalm, M. C., Harris, K., Quince, C., Jernberg, C., ... & Andersson, A. F. (2013). Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section. Gut. Joseph, C. L., Ownby, D. R., Havstad, S. L., Woodcroft, K. J., Wegienka, G., MacKechnie, H., ... & Johnson, C. C. (2011). Early complementary feeding and risk of food sensitization in a birth cohort. Journal of Allergy and Clinical Immunology, 127(5), 1203-1210. McNeill, G., Tagiyeva, N., Aucott, L., Russell, G., & Helms, P. J. (2009). Changes in the prevalence of asthma, eczema and hay fever in pre‐pubertal children: a 40‐year perspective. Paediatric and perinatal epidemiology, 23(6), 506-512. Smallwood, J., & Ownby, D. (2012). Exposure to dog allergens and subsequent allergic sensitization: an updated review. Current allergy and asthma reports,12(5), 424-428. Images Daniel Stockman: http://www.flickr.com/photos/evocateur/6365009983/ Carmen Rodriguez: http://www.flickr.com/photos/carmenherbs/11166111013/ 23am.com: http://www.flickr.com/photos/23am/3817278904/ Hernan Mojarro: http://www.flickr.com/photos/hmojarro/2517666578/ Din Muhammad Sumon: http://www.flickr.com/photos/dmsumon/6565661817/ Katherine/tintedglass: http://www.flickr.com/photos/tintedglass/3943681096/ Jerry Frausto: http://www.flickr.com/photos/gorefiendus/3432756019/
Views: 3626557 MinuteEarth
Cardiovascular Pharmacology - 01 - Therapy of hypertension
 
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Video lectures in clinical pharmacology by Dr. Abdel-Motaal Fouda, associate professor of clinical pharmacology, Mansoura Faculty of Medicine. 2016. foudaamm@mans.edu.eg
Views: 38463 Abdel-Motaal Fouda
FITZGERALD FNP BOARDS REVIEW | Review of the Review & Life Updates | Weekly Vlog No. 11
 
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In this weeks Day in the Life of a NP New Grad video I’ll take you along on my Fitzgerald Live Board Prep Family Nurse Practitioner Review. I attended Fitzgerald’s Live Review for Family Nurse Practitioners, in preparation for my Family Nurse Practitioner Boards exam that I will be taking in the next few weeks. Overall, I found the content and presentation to be very well done! I had a few concerns that I talked about in the video, but overall It was good! I included a few tips for those who ever attend a review like this to promote concentration and learning! As usual, I’ll update everyone on my search for a Family Nurse Practitioner Job. I’ll also give the usual Avery and Family updates, and you can see my excellent yard keeping skills. HAH. not. Although, I did transplant a Peony last year that I found growing out of the cement, and it is THRIVING despite my brown thumb. Who would have thought?! If you are new here, Hello! I’m Liz. A pediatric nurse, new(ish) mom, and recent graduate from a Family Nurse Practitioner Program. I’m currently searching for a Job and studying for my boards exam! To learn more about me, click here — https://youtu.be/WvAIdYcwNPQ I had a baby in NP school. It was crazy. to see more about that, click here — https://youtu.be/8MDyYrpM2Ag Want to see what my RN job looks like? Click here — https://youtu.be/TykAHBT5olg Lets be Friends! Instagram: https://www.instagram.com/im.nurse.liz/ Have a video request? send me a message on IG! Some of my Absolute Favorite Nursing, Life and NP Goodies from this video: These compression socks are MIRACLE workers for your tired legs:: https://amzn.to/2GWNQCi Eufy, The Sanity Saving Robot Vacuum: https://amzn.to/2reM5tF Carseat/High Chair/Shopping Cart/Nursing Cover (fits over Costco carts!): https://amzn.to/2JJltJH Super Durable Water Bottle: https://amzn.to/2qxjoII Leuchtturm1917 Bullet Journal (this is how I keep my life organized and my mind clear): https://amzn.to/2GXe7V9 Leuchtturm Small Notebook for Clinical: https://amzn.to/2ITqSwr FNP Boards Review Book by Leik (comes with free app with all content on it): https://amzn.to/2qxK3Eq Pop Socket (Rose Gold): https://amzn.to/2qwtQzj Best Reference Book for all things Anti-Infective: https://amzn.to/2GX4oOF Current Medical Diagnosis and Treatment (This book is a MUST HAVE, especially for clinical): https://amzn.to/2HLQPy2 Baby Jail: https://amzn.to/2IMw4Xt Disclaimer: I receive commission off of sales made through the links above. This does not cost you any extra & I appreciate your support SO much!
Views: 498 Nurse Liz
50 SCIENTIFICALLY PROVEN BENEFITS OF KUNDALINI YOGA AND KUNDALINI MEDITATION
 
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50 SCIENTIFICALLY PROVEN BENEFITS OF KUNDALINI YOGA AND KUNDALINI MEDITATION Scientific studies about yoga meditation show proof behind the benefits of yoga meditation. We bring you 50 of scientifically proven benefits of yoga meditation: 1. Yoga is more effective than relaxation in reducing high blood pressure according to Lancet study in 1975. 2. Yoga can help in bronchial asthma according to British Medical Journal in 1985. 3. Meditation decreases the depression, ruminative thinking, dysfunctional beliefs, anxiety and stress, a University of California study concluded. 4. Reduces depression in mothers to be, a University of Michigan Health System study shows. 5. Meditation regulates mood and anxiety disorders, show studies by PubMed, Cochrane Databases and PsycInfo. 6. Yoga benefits for carpal tunnel syndrome, shows a study organized by JAMA in 1998. 7. Yoga is an effective treatment for chronic lower back pain, a study by Annals of Internal Medicine in 2005. 8. Meditation helps to reduce stress and anxiety in general according to a study by University of Wisconsin-Madison. 9. Meditation reduces the symptoms of panic disorder, according to published research by American Journal of Psychiatry. 10. Meditation improves the concentration in the brain, learning, memory, sense of self, and regulate emotion, shows an experiment of a group of Harvard neuroscientists on 16 people. 11. Yoga helps in life-threatening diseases, shows a study of Journal of the American College of Cardiology in 2013. 12. 20 Minutes a day Meditation improves your performance and ability to work in stress, concludes a study in UK. 13. Meditation improves decision-making, finds UCLA Laboratory of Neuro Imaging. 14. Meditation gives you resilience and emotional intelligence, according to psychotherapist Dr. Ron Alexander. 15. Yoga can increase flexibility, shows Journal of Strength and Conditioning Research in 2013. 16. Meditation can make you stronger against pain, finds University of Montreal research on 13 Zen masters and 13 comparable non-practitioners. 17. Yoga can help women with breast cancer, demonstrates Journal of Clinical Oncology in 2014 in a study. 18. Meditation improves psychomotor vigilance and decrease sleep need, finds a research by the University of Kentucky. 19. Meditation enhances the ability to generate gamma waves in the brain, reveals a study by the neuroscientist Richard Davidson of the University of Wisconsin. 20. Yoga can reduce inflammation as evidenced in review of the evidence on yoga in 2015. Visit SimplifiedKundaliniYoga.com Awaken Your Kundalini. Meditate to awaken your body, mind and soul. Be Blessed by the Divine, Krish Murali Eswar. Visit Website: http://naturopathyoga.org/sky http://naturopathyoga.org/kky http://www.SimplifiedKundaliniYoga.com http://www.KayaKalpaYoga.com
Signs and Symptoms of Vitamin B12 Deficiency You Should Not Ignore
 
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Descriptions of Signs of Vitamin B12 Deficiency: Why is vitamin B12 important and where can i get vitamin b12? Vitamin B12 is vital for the formation of red blood cells that carry oxygen around the body. It is also needed for the proper functioning and health of nerve tissue, as it is involved in producing the protective myelin sheath that covers the nerves and conducts nerve impulses. It works together with folate in the metabolism of cells, especially affecting DNA synthesis and fatty acid and amino acid metabolism. This particular B vitamin also helps our bodies absorb folic acid, which facilitates the release of energy. Since your body doesn’t make vitamin B12, it is important to get it from food sources (especially animal-based foods, fruits with vitamin b12) or supplements on a regular basis, vitamin b12 serum, b12 energy or vitamin b12 supplement. Always consult your doctor before starting any supplement regimen. Here are the top 5 signs of vitamin B12 deficiency. review : 01:02 Fatigue and Low Energy 02:05 Numbness and Tingling Sensations 03:08 Low Blood Pressure 04:06 Skin Lesions 05:11 Depression 1. Fatigue and Low Energy This vitamin plays a prominent role in energy metabolism, hence its deficiency has a direct impact on your energy and endurance levels. Vitamin B12 enhances your body’s ability to make DNA for new cells to provide energy. It is also needed to form healthy red blood cells that carry oxygen to the whole body. Without proper oxygen levels, you feel tired and lethargic. Plus, B12 is needed to turn the food you eat into energy to power your metabolism. Low metabolism prevents you from feeling your best and performing at your highest energy level. 2. Numbness and Tingling Sensations Vitamin B12 plays a key role in keeping your nervous system healthy. Thus, neurological signs like numbness or a tingling sensation in the hands and feet can indicate its deficiency. Vitamin B12 helps in the manufacturing of nerves and, moreover, it has a key role in helping oxygen reach different parts of the body. Poor oxygen supply is one of the main causes of numbness and tingling sensations. Its deficiency can also cause balance problems. 3. Low Blood Pressure Deficiencies of vitamin B12 and folic acid can cause anemia, which can lead to low blood pressure, also known as hypotension. Vitamin B12 helps your body produce red blood cells so that adequate oxygen reaches each and every part of your body, including the heart. A 2012 study published in the Texas Heart Institute Journal reports that vitamin B12 deficiency is well known among neurologists but is often overlooked by cardiologists when treating low blood pressure. If you suffer from low blood pressure, opt for a B12 test. Even moderate forms of low blood pressure can cause shortness of breath, dizziness, weakness, fainting and risk of injury from falls. 4. Skin Lesions Low vitamin B12 can also cause skin lesions and hair changes. A 2008 study published in Canadian Family Physicians reports that vitamin B12 deficiency is linked to skin lesions. Unexplained and non-resolving skin lesions can signal vitamin B12 deficiency, hence you need to visit your doctor as soon as possible. Along with skin lesions, its deficiency can cause hyperpigmentation of the skin, which leads to uneven skin color and dark patches on the skin. 5. Depression This particular B vitamin is also essential for mental health. Its role in forming red blood cells in turn helps support a healthy nervous system. Plus, it helps lower the level of homocysteine, a by product of protein metabolism. A high level of homocysteine in the body can lead to depression. This is why it is important to consider the possibility of B12 deficiency, especially among the elderly suffering from depression, according to a 2009 study published in the Journal of Clinical Psychiatry emphasis upon. In fact, a 2013 study published in the Open Neurology Journal shed light on the importance of vitamin B12 supplementation in the treatment of major depressive disorder. The study found that people with depression experienced significant improvement in symptoms when treated with vitamin B12 supplementation as well as antidepressants. Music: Royalty Free Music from Bensound
Views: 138426 Signs And Symptoms
Tea Tree Oil Healing, 80+ Uses,  Acne, Asthma, Immune Stimulant, Cold Sores, Fungus, Parasites
 
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Tea tree oil (TTO), also called melaleuca oil, is made from the leaves of the tea tree plant (Melaleuca alternifolia), a member of the myrtle tree family, which is native to Australia. The name was coined by British explorer Lieutenant James Cook in the 1770s, when he saw native Australians brewing tea using the leaves from the tree. Later on, he brewed his own batch of tea, and gave it to his crew to prevent scurvy. The tea tree plant is highly prized by primitive Australian communities for its unique healing ability. According to the University of Sydney, numerous aboriginal communities along the east coast of Australia have a long historical use of tea tree as an antiseptic for skin conditions. They simply crushed the tea tree leaves and applied it to cuts, burns, and infections.Tea tree oil has gained a reputation for being an all-around remedy, from removing makeup to treating warts.Numerous studies have been conducted to prove the potential benefits of tea tree oil for health ailments, such as: Acne - A comparative study published in the Medical Journal of Australia found that TTO and benzoyl peroxide both had a significant effect in ameliorating patients' acne. Although the onset of action in tea tree oil was slower, it caused fewer side effects than benzoyl peroxide. Fungal infections - A study published in the journal Tropical Medicine and International Health found that treating toenail onychomycosis with 2% butenafine and 5% TTO in cream cured 80 percent of patients. Bacterial infections – A 2004 study funded by the National Center for Complementary and Alternative Medicine (NCCAM) found that TTO may be used as an adjunctive treatment for wounds, and may even help treat severe infections like methicillin-resistant Staphylococcus aureus (MRSA). However, large, well-designed clinical trials are lacking, and the jury is still out on whether tea tree oil really has this potential. Smaller-scale clinical studies on tea tree oil revealed TTO's potential for treating athlete's foot, dandruff, lice, gingivitis, and genital infections. In aromatherapy, tea tree oil is said to be helpful in alleviating chest and head congestion, stuffy nose, and other symptoms of colds and flu, especially when used in steam inhalation. Steam inhalation clears the congested nasal passages and kills bacteria. Adding an antiviral essential oil like TTO makes it that much more effective. Just add a few drops to a steaming bowl of hot (purified) water, cover your head with a towel, and breathe in the vapors for five to 10 minutes. Adding a few drops of tea tree oil to your bathwater may also help stop a cold from developing. Risks and FYI~ Tea tree oil contains varying amounts of 1,8–cineole, a skin irritant that may cause allergic reactions in some individuals. The rashes are usually mild and itchy, but may also lead to blistering. Serious allergic reactions may also occur. There are other reported instances of dizziness and swelling in his throat. DO NOT swallow or ingest tea tree oil. It may cause severe reactions, such as rashes, blood cell abnormalities, diarrhea, stomachache, nausea, vomiting, drowsiness, hallucinations, and ataxia (loss of muscle control in the arms and legs). Tea tree oil may also be toxic to pets if ingested. Veterinary toxicologists found that large amounts of undiluted tea tree oil applied to the skin of cats and dogs caused a hypersensitivity (allergic) reaction. If you are allergic to eucalyptol, use TTO with caution, as many formulas are mixed with eucalyptol..My videos are not intended to treat, or diagnose. For serious medical conditions seek the advice of a natural health care provider. Peace, Love, and Positive Vibrations~ Have a wonderful day~ Thank you for your love and support.
Dr. Szefler and Dr. Wechsler discuss JACI paper on Bronchial Thermoplasty.
 
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Stan Szefler, MD talks with Michael Wechsler, MD about Dr. Wechsler's new JACI article "Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma". This article is available with free access here: http://www.jacionline.org/article/S0091-6749(13)01268-2/fulltext Key words: Bronchial thermoplasty, asthma, bronchoscopic procedure, Alair System, asthma exacerbation
Views: 507 JAllergyClinImmunol
Cardiovascular Pharmacology - 02 - Calcium channel blockers
 
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Video lectures in clinical pharmacology by Dr. Abdel-Motaal Fouda, associate professor of clinical pharmacology, Mansoura Faculty of Medicine. 2016. foudaamm@mans.edu.eg
Views: 17944 Abdel-Motaal Fouda
Charité Clinical Journal Club by Fred Luft - 16.07.2014
 
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The N Engl J Med image of the week shows a man with a red face. You are offered auriculotemporal nerve syndrome, carcinoid syndrome, mastocytosis, pheochromocytoma, and rosacea. We go over each condition. We revisit the case from last week with sternal tuberculosis and review his CT scan. Exemestane is an aromatase inhibitor that blocks the conversion from testosterone to estrogen. Adjuvant therapy with an aromatase inhibitor could improve outcomes, as compared with tamoxifen, in postmenopausal women with hormone-receptor--positive breast cancer. Investigators randomly assigned premenopausal women with hormone-receptor--positive early breast cancer to exemestane plus ovarian suppression or tamoxifen plus ovarian suppression for a period of 5 years. Suppression of ovarian estrogen production was achieved with the use of the gonadotropin-releasing-hormone agonist triptorelin, oophorectomy, or ovarian irradiation in both groups. Exemestane reduced disease recurrence, but not overall survival. Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result in better pregnancy outcomes. Letrozole beat clomiphene in these BMI 35 ladies. Dupilumab, a fully human monoclonal antibody, which blocks interleukin-4 and interleukin-13, has shown efficacy in patients with asthma and elevated eosinophil levels. The blockade by dupilumab of these key drivers of type 2 helper T-cell (Th2)--mediated inflammation could help in the treatment of related diseases, including atopic dermatitis. The findings provide evidence that allergic asthma and atopic dermatitis might have related drivers — in particular, interleukin-4 and interleukin-13 — and that these diseases may benefit from the same therapeutic approach. In the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY), newborns with asphyxial encephalopathy receiving hypothermic therapy had improved neurologic outcomes at 18 months of age, but it is uncertain whether such therapy results in longer-term neurocognitive benefits. Now we are certain. The recent outbreak of Exserohilum rostratum meningitis linked to epidural injections of methylprednisolone acetate has brought renewed attention to mold infections of the central nervous system (CNS). Although uncommon, these infections are often devastating and difficult to treat. We review the topic. The mystery case of the week is a 68-year-old man with ANCA vasculitis who develops diplopia and other CNS manifestations. In the Lancet, evidence suggests that brief physiotherapy programs are as effective for acute whiplash-associated disorders as more comprehensive programs; however, whether this also holds true for chronic whiplash-associated disorders is unknown. Turns out that brief treatment is as good as comprehensive physiotherapy for long-term whiplash results. Postoperative surgical site infections are one of the most frequent complications after open abdominal surgery, and triclosan-coated sutures were developed to reduce their occurrence. The aim of the PROUD trial was to obtain reliable data for the effectiveness of triclosan-coated PDS Plus sutures for abdominal wall closure, compared with non-coated PDS II sutures, in the prevention of surgical site infections. Unfortunately, triclosan did not help. Poor adherence to treatment diminishes its individual and public health benefit. Financial incentives, provided on the condition of treatment attendance, could address this problem. Injecting drug users (heroine addicts) are a high-risk group for hepatitis B virus (HBV) infection and transmission, but adherence to vaccination programs is poor. Investigators aimed to assess whether contingency management (paying them to complete vaccination) delivered in routine clinical practice increased the completion of HBV vaccination in individuals receiving opioid substitution therapy. Bribes generally work. We then inspect an important meta-analysis of breast cancer patients treated with neoadjuvant chemotherapy (more advanced disease given chemotherapy before surgery). A "pathological complete response" is deemed to be an important prognostic indicator. We learn the prognostic value and limitations of this pathological result. The Lancet case is a 92 year-old lady with knee pain that turns out to be an obturator hernia. We review this treacherous diagnosis.
Forskolin: It’s What You Don’t Know About It That Could Shock You
 
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http://ForskolinCouponCodes.com/ For many generations now herbal medical practitioners have been using a miraculous plant to treat various heart conditions including high blood pressure and chest pains. Its also been used to treat respiratory conditions such as asthma. This miraculous plant is known as the Coleus Forskohlii that contains Forskolin. It is the Forskolin that is responsible for many of these curative properties. In recent years, Forskolin has taken the spotlight because of its multitude of health benefits. Many research studies were conducted to understand the chemical composition of this compound, which our ancestors may already have known. The most common benefit of Forskolin is helping people lose weight and alleviate cardiovascular conditions. In addition to the cardiovascular benefits of Forskolin, there are many health benefits associated with taking this miraculous chemical. Many consider these additional benefits as “icing on the cake” once they startlosing excess weight. As stated, Coleus Forskohlii has been used since ancient times in treating heart disorders and other related cardiovascular conditions such as high blood pressure. Because Forskolin comes from this plant, it contains the same chemical substances that help treat high blood pressure and chest pains. Forskolin is effective in lowering high blood pressure and minimizing chest pains by widening the walls of the blood vessels. In fact, there are medical practitioners that inject Forskolin into their patients intravenously to treat heart conditions. In the past, several research studies revealed the Forskolin is also an effective treatment for asthma. In 2006, a clinical study was conducted involving 40 adults and children with mild to moderate persistent asthma. These adults and children were closely monitored for 6 months. In the clinical study researchers found that asthma attacks were significantly less frequent among those who took Forskolin capsules compared to those who took common asthma treatments. The results of the research study were published in the Journal of International Medical Research. Forskolin has shown be an effective treatment for skin disorders when taken orally. It is effective in treating mild cases of skin allergies, as well as severe skin conditions such as eczema and psoriasis. Furthermore, Forskolin is known to treat glaucoma when used as eye drops. Those wishing to take in the sun and tan their skin, Forskolin can also help in that aspect. A research study was conducted and revealed that Forskolin helps work on your tan when applied directly to the skin. The Forskolin helps manipulate the pigmentation of the skin and prompt tanning of the skin without exposure to UV light. However, additional clinical and research studies are still underway to solidify this tanning benefit of Forskolin. As you can see, the health benefits of Forskolin are vast. While many take Forskolin for the powerful weight loss aspects, these other advantages can prove beneficial for those looking to drop a few pounds as well as those already at an optimal weight. We hope that you've enjoyed this video from PacificCoast NutriLabs about the power of forskolin and obtaining your weight loss goals. As a special limited time opportunity, we want to offer you 40% off on our maximum potency PLATINUM Series Forskolin, which is backed by our 100% money back Best Health Guarantee. All you have to do is go to http://www.ForskolinCouponCodes.com and use the promo code KAXCRSD4 at checkout! If you want to learn more about forskolin health benefits, check out our blog at http://PacificCoastNutriLabs.com/blog To view this video online visit: http://youtu.be/PfyxxkhpMsk Let's connect! - Facebook: https://www.facebook.com/PacificcoastNutrilabs - Twitter: http://www.Pinterest.com/PCNutrilabs - Pinterest: https://twitter.com/PCNutriLabs - Our blog: http://PacificCoastNutriLabs.com/blog Go to http://www.ForskolinCouponCodes.com use promo code KAXCRSD4 at checkout to save 40% on our PLATINUM Series Forskolin.
Pathophysiology and Mechanism of Glucocorticoids to treat ASTHMA
 
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In this video we are going to discuss about the Pathophysiology and mechanism of Glucocorticoids to treat asthma Share, Support, Subscribe!!! Facebook: https://www.facebook.com/conceptclearr/ Youtube : https://www.youtube.com/channel/UC8ncgULJ1HEkWGz5uuyfmvw?sub_confirmation=1
Views: 133 Concept Clear
Case reports link HFCS to asthma autoimmune full video.
 
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Case reports link HFCS (high fructose corn syrup), and fructose malabsorption to incidence of asthma, auto-immune reactivity, and chronic lung disease. For more than 15 years pediatricians and the medical community have heard reports, yet the link remains medically unrecognized and unresearched.
Views: 93 LRD Christopher
How to find a Scholarly Journal Article in a Nyack/ATS Library Database
 
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A short tutorial explaining how to find a scholarly journal article in a Nyack/ATS Library database
Views: 645 NyackATSLibs
Charité Clinical Journal Club by Fred Luft - 10.8.2016
 
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The N Engl J Med image of the week shows a PA chest roentgenogram. The cardiac silhouette looks like a large Erlenmeyer flask. You are offered superior vena cava syndrome, dilated thoracic aorta, cardiac tamponade, and giant right atrium. We discuss these conditions. The Amish and Hutterites (immigrants from Germany circa 17th century) are U.S. agricultural populations whose lifestyles are remarkably similar in many respects but whose farming practices, in particular, are distinct; the former follow traditional farming practices whereas the latter use industrialized farming practices. The Amish children are oddly almost immune to developing asthma, while the Hutterite children develop asthma six-times more frequently and are no different than the US mean. You will recall that “wallowing in the dirt” as a young child is said to protect from asthma. Investigators studied environmental exposures, genetic ancestry, and immune profiles among 60 Amish and Hutterite children, measuring levels of allergens and endotoxins and assessing the microbiome composition of indoor dust samples. Whole blood was collected to measure serum IgE levels, cytokine responses, and gene expression, and peripheral-blood leukocytes were phenotyped with flow cytometry. The effects of dust extracts obtained from Amish and Hutterite homes on immune and airway responses were assessed in a murine model of experimental allergic asthma. The genes were no different, but the innate immune responses certainly were. Hidradenitis suppurativa is a painful, chronic inflammatory skin disease with few options for effective treatment. In a phase 2 trial, adalimumab, an antibody against tumor necrosis factor α, showed efficacy against hidradenitis suppurativa. PIONEER I- and II-studies were similarly designed, phase 3 multicenter trials of adalimumab for hidradenitis suppurativa, with two double-blind, placebo-controlled periods. Adalimumab resulted in significantly higher clinical response rates in both trials at 12 weeks, while rates of serious adverse events were similar in the study groups. Forty years ago, as a young U.S. Army physician, I learned that recruits with hemoglobin SA (about 10% of black Americans) were at risk for developing rhabdomyolysis if severely stressed by heat-related exercise. Investigators now used Cox proportional-hazards models to test whether the risks of exertional rhabdomyolysis and death varied according to sickle cell trait status among 47,944 black soldiers who had undergone testing for HbAS and who were on active duty in the U.S. Army between January 2011 and December 2014. There was no risk of death; however, rhabdomyolysis with extreme heat-related exercise occurred as I was taught (better late than never). Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes among men with localized prostate cancer who are unselected for family predisposition is insufficient to warrant routine testing, the frequency of such mutations in patients with metastatic prostate cancer has not been established. We inspect a study that establishes the frequency. The incidence of germline mutations in genes mediating DNA-repair processes among men with metastatic prostate cancer was 11.8%. The N Engl J Med review is on fire-related inhalation injury. The “coconut grove fire” in Boston 1942 is the prototype example. The weekly case involves a 72 year-old man who is operated upon both knees and receives cefazolin prophyaxis. Two days later, fever and a rash occur. Could this be an example of “drug reaction with eosinophilia and systemic symptoms (DRESS syndrome)” even though the eosinophils range only at 3%? Mantle cell lymphoma is characterized by a poor long-term prognosis. Lancet investigators tested to see if high-dose cytarabine given prior to autologous stem-cell transplantation would help. It did. Few options remain for patients with extremely aggressive multiple sclerosis. We inspect a study of near-complete immunoablation followed by autologous hematopoietic stem-cell transplantation with rather impressive results. In 2000, a 10-year Teenage Pregnancy Strategy was launched in England to reduce conceptions in women younger than 18 years and social exclusion in young parents. Teenage pregnancies have decreased in the UK. We next inspect the case of a 2 week-old girl with severe hypokalemia, metabolic alkalosis and renal failure with renal insufficiency. At a later date, an apparent hearing loss is identified. We close the session with reviewing the case of a 59 year-old Lupus erythematosis patient who develops lethargy, somnolence, tachypnea, and fever.
International Journal of Case Reports and Images - Edorium Journals - 2013
 
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Cover page images of 2013. International Journal of Case Reports and Images (IJCRI), is a very high quality, international, peer reviewed, open access case reports journal publishing case series and case reports in all medical and surgical specialties. The journal is published in 12 issues every year. This case reports journal is managed by a team of highly experienced, multinational editorial board. All articles submitted to the journal undergo editorial review followed by external expert peer review. Articles are published in the following formats: Review articles, Case series, Case reports, Case in Images, Clinical images, Letter to editors and Editorials. The "submission to first decision" time is 28-42 days and "submission to publication" time is about 12-16 weeks. Journal website: http://www.ijcasereportsandimages.com
Views: 77 Edorium Journals
Asthma in children: Guidelines for primary care management
 
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Dr. Thomas Saba, pediatric pulmonologist, presents best practices for primary care providers in the care of pediatric patients with asthma. Presented at the 2018 Partners in Pediatric Care CME. Learn more about University of Michigan C.S. Mott Children's Hospital's services for children with asthma at https://www.mottchildren.org/conditions-treatments/peds-respiratory-care/asthma
Views: 25 Michigan Medicine
Allergy & Asthma Misinformation in Popular Culture
 
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Allergy and Asthma Misinformation in Popular Culture: Responding to the Marketing of Unproven Therapies In this AllerGen webinar, presented April 11, 2017, the presenter--Prof. Timothy Caulfield--reviews what the available evidence says about misinformation in popular culture on how to treat and diagnose allergy and asthma, and shares insights from his team’s research on the services offered by complementary and alternative practitioners. He also discusses ways researchers can respond to misinformation, taking into consideration relevant laws, policies and science communication strategies.
Views: 72 AllerGen NCE
SERRAPEPTASE - AMAZING ENZYME FOR PAIN AND STIFFNESS!
 
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Collin Chi, C.N.C. discusses one of his favorite, fast-acting supplements for breaking up a protein called fibrin which can cause muscle pain, joint pain, tightness, tension, and stiffness in the body. Consultation: collinchi@gmail.com References: https://www.ncbi.nlm.nih.gov/pubmed/15454707 https://www.ncbi.nlm.nih.gov/pubmed/9389219 http://www.journal-surgery.net/article/S1743-9191(13)00026-5/fulltext https://www.ncbi.nlm.nih.gov/pubmed/22037947 Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb;30(1):48-54. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990 Sep-Oct;18(5):379-88. Kakinuma A, Moriya N, Kawahara K, Sugino H. Repression of fibrinolysis in scalded rats by administration of Serratia protease. Biochem Pharmacol. 1982 Sep 15;31(18):2861-6. Esch PM, Gerngross H, Fabian A. [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase– a prospective study]. Fortschr Med. 1989 Feb 10;107(4):67-8, 71-2. German. http://aac.asm.org/content/37/12/2618.full.pdf Antibiotic susceptibility tests showed that serratiopeptidase (Serrapeptase ) greatly enhances the activity of the antibiotic, ofloxacin, and that it can inhibit biofilm formation. [Antimicrob Agents Chemother. 1993; 37(12): pp.2618-21] http://www.ssu.ac.ir/fileadmin/templates/fa/Marakeze_Tahghighati/ijpho/issue2/3.pdf http://umm.edu/health/medical/altmed/herb/turmeric https://academic.oup.com/aje/article/163/3/222/59715/Nut-and-Seed-Consumption-and-Inflammatory-Markers https://www.researchgate.net/publication/255973753_Testosterone_and_acute_stress_are_associated_with_fibrinogen_and_von_Willebrand_factor_in_African_men_The_SABPA_study https://www.researchgate.net/publication/21701603_Changes_in_blood_lipids_and_fibrinogen_with_a_note_on_safety_in_a_long_term_study_on_the_effects_of_n-3_fatty_acids_in_subjects_receiving_fish_oil_supplements_and_followed_for_seven_years http://ajcn.nutrition.org/content/76/6/1249.full http://www.nature.com/nrrheum/journal/v8/n12/full/nrrheum.2012.184.html
Views: 49617 RISE FIT
Case Study - UTI, Pneumonia and Febrile Neutropenia
 
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Pediatric oncall a video created about some really unbelievable medical cases of Urinary tract infection, pneumonia and febrile neutropenia that helps Doctors & Medical students. Watch the video to learn more :-) WEBSITE: http://www.pediatriconcall.com/ SUBSCRIBE TO YOUTUBE: https://www.youtube.com/user/pediatriconcallvideo FOLLOW US ON: https://www.facebook.com/PediatricOncall/ https://twitter.com/pediatriconcall https://plus.google.com/+Pediatriconcall/posts Urinary tract infection-prevent this situation secondary to recurrent UTI, What are the risk factors UTI, worry about recurrent UTI, drug treatment of recurrent UTI and how to take care of Pneumonia in children- Persistent difference recurrent pneumonia, what are the likely causes of patient, what are the common organisms that cause recurrent pneumonia and antibiotic of choice, Why are Asthma and Tb mentioned as causes of recurrent pneumonia, Congenital anomalies leading to recurrent pneumonia and clinical examination. Febrile Neutropenia-How to diagnose catheter related infection, How to choose an anti-fungal agent, what common cause febrile neutropenia, How long to give antibiotics and Key message for managing a child with febrile neutropenia… -~-~~-~~~-~~-~- Please watch: "Dr. Rakesh Kumar : About India's Vaccine Scenario | pediatric Oncall " https://www.youtube.com/watch?v=UVn6k5moI2s -~-~~-~~~-~~-~-
Views: 6317 Pediatric Oncall
Djenkolism case report - Video abstract 58379
 
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Video abstract of case report paper Djenkolism: case report and literature review published in the open access International Medical Case Reports Journal by Nur C Bunawan, Asghar Rastegar, Kathleen P White, et al. Abstract: Djenkolism is an uncommon but important cause of acute kidney injury. It sporadically occurs after an ingestion of the djenkol bean (Archidendron pauciflorum), which is native to Southeast Asia. The clinical features defining djenkolism include: spasmodic suprapubic and/or flank pain; urinary obstruction; and acute kidney injury. The precise pathogenesis of acute kidney injury following djenkol ingestion remains unknown. However, it is proposed that an interaction between the characteristics of the ingested beans and the host factors causes hypersaturation of djenkolic acid crystals within the urinary system, resulting in subsequent obstructive nephropathy with sludge, stones, or possible spasms. We report a case of djenkolism from our rural clinic in Borneo, Indonesia. Our systematic literature review identified 96 reported cases of djenkolism. The majority of patients recovered with hydration, bicarbonate therapy, and pain medication. Three patients required surgical intervention; one patient required ureteral stenting for the obstructing djenkolic acid stones. Four of the 96 reported patients died from acute kidney failure. We stress the importance of awareness of djenkolism to guide medical practitioners in the treatment of this rare disease in resource-poor areas in Southeast Asia. Read the full paper here: http://www.dovepress.com/djenkolism-case-report-and-literature-review-peer-reviewed-article
Views: 460 Dove Medical Press
Cardiovascular Pharmacology - 08 - Other antianginal drugs and AMI
 
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Video lectures in clinical pharmacology by Dr. Abdel-Motaal Fouda, associate professor of clinical pharmacology, Mansoura Faculty of Medicine. 2016. foudaamm@mans.edu.eg
Views: 10532 Abdel-Motaal Fouda
Mayo Clinic Study Finds Increased Risk of Pneumococcal Disease in Asthma Patients1
 
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Mayo Clinic research shows adults with asthma are at increased risk of serious pneumococcal disease caused by Streptococcus pneumoniae, the most common bacteria causing middle ear infections and community acquired pneumonia. It also causes blood stream infections and brain infections. According to the Centers for Disease Control, pneumococcal infection is one of the leading causes of death from a vaccine-preventable disease. The researchers recommend including asthma as an indication for pneumococcal vaccination in adults. The results of the study were recently published in the October edition of the Journal of Allergy and Clinical Immunology. Young Juhn, M.D., a pediatric and adolescent medicine physician-scientist at Mayo Clinic and lead author of the study provides an overview.
Views: 398 Mayo Clinic
Differential diagnoses through an expanded VITAMINSABCDEK
 
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Video abstract of Rapid Communication type paper “Practical way of creating differential diagnoses through an expanded VITAMINSABCDEK mnemonic” published in the open access journal Advances in Medical Education and Practice by author Zabidi-Hussin. Abstract: Having an organized, structured thinking process is critical in medicine. It is through this thinking process that enables one to go through the method of history-taking, which will eventually lead to making a definitive diagnosis and all other processes that follow. The use of mnemonic has been found to be useful for this purpose. The mnemonic VITAMINSABCDEK, is a convenient and practical way to assist in expanding the differential diagnoses and covers all possible causes of an illness. It is also easy to remember, as the vitamins whose letters are represented in this mnemonic cover the entire range of vitamins known. Read the rapid communication paper here: https://www.dovepress.com/practical-way-of-creating-differential-diagnoses-through-an-expanded-v-peer-reviewed-article-AMEP
Views: 493 Dove Medical Press
Top 4 Natural Vitamins to Boost Your Memory, Focus, and Mental Clarity
 
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Learn more: http://brainenhancingnootropics.com/ Do you want to boost your memory, focus, and mental clarity? Do you want that mental edge to keep you going every day to be at the peak of your game? Here are 4 earth growing nutrients that you can take daily to help improve your brain power. 1. Bacopa Has been used for centuries in the traditional Ayurvedic medical system of India to improve memory and longevity, possessing both antioxidant and adaptogenic properties. It has been used in traditional treatment for epilepsy and asthma Clinical trials in humans have found promising evidence for memory recall. 2. Huperzia Serrata A naturally derived acetylcholinesterase inhibitor. Acetylcholinesterase (AchE) is responsible for the breakdown of Acetylcholine, and so by inhibiting AchE, more acetylcholine is made available to the brain. Is a rare Chinese herb used for centuries. According to study, it has been proven to be beneficial in protecting the brain, including slowing the progression of Alzheimer’s disease. 3. Oat Straw An alleviator of neurological stress and exhaustion, which has been shown to have a positive impact on cognitive performance in healthy subjects. It uses behavioral agents dates back to at least the Middle Ages. The extract has the ability to reduce two enzymes tied to depression the same way some prescription medications do. A double-blinded study, published in the “Journal of Alternative and Complementary Medicine”, in May 2011, showed some improvements in cognitive performance in healthy subjects. 4. Cat’s Claw A plant revered by traditional cultures for its antioxidant and immune-boosting properties. A natural treatment for arthritis, allergies, asthma, diabetes, chronic fatigue syndrome, cancer, viral infections and more. This woody vine native to the Amazon rainforest can help many serious health problems by assisting the body in eliminating free radicals that cause cellular damage. Taking these natural vitamins on a daily basis will boost your memory, processing speed and focus. It will give you the edge you need to be at your best so you can accomplish your daily task. Don’t want to take four different vitamins daily? We have great news. All the above powerful brain vitamins are now available in one easy supplement. To learn more, you can go to the main page and check out this amazing brain supplement at http://brainenhancingnootropics.com/