Velocitizing longevity research
Create a group of 40 cohorts (groups)
of 11 mice each
Where each cohort is a different month of age
Then the monthly progression of new data from
the progressively deceasing ( ) mice quantifies the longevization effects of new molecules more rapidly.
The researcher gets a p value after 2 or 3 months, giving them the ability to find better molecules or collaborate on novel cause research earlier, as well as publishing.
The fresh monthly data from the progressively deceasing mice causes molecule longevity research to be 10 or 20 times higher velocity (3 month early valid data compared with 36 month data value)
Amplifying that effect further Mouse facilities, like Wistar Institute, could create prearranged cohort (age month) groups as a researcher specified, standardized product.
Numerous published researchers have noted that just causing greater longevity defers things like cancer or cardiovascular disease, effectively preventing them during any particular age range.
Thus all longevity reseach is also perceivable as cancer prevention, heart disease prevention research, Benefiting humans.
Wistar or another mouse provider (like a university mouse colony) would create a statistically portable model perhaps like
At the protocol start there are
11 mice at 39 months of age
11 mice at 38 month of age
11 mice at 37 months of age
11 mice at one month of age
at the beginning
(My minimally informed mathematics suggests that 9 mice per cohort would be minimum to get a p value, perhaps 11 is better.)
Along with a protocol that says “use these published equations or software to process your Wistar cohort data automatically.”
The published equations or software could automatically gather groups of cohorts to do meta analysis of the effect of a longevity molecule at early youth, midspan, or aged mice. Noting that these could vary.
Benefits of velocitizing longevityresearchThere are many chemicals published as giving greater longevity, recently ibuprofen among them. Noting that ibuprofen is already widely available, being able to describe the beneficial effects a year early, possibly represents 15/100 of human longevity or greater. Bringing this to people a year early represents more than 10 million person years of improved longevity (per 2014 AD Earth population), just from using a different new research protocol.
This video supports the creation of a new velocitized longevity research protocol. Create a group of 40 cohorts (groups) of 11 mice each, where each cohort is a different month of age. Then the monthly progression of new data from the progressively deceasing mice quantifies the longevization effects of new molecules more rapidly.
The researcher gets a p value after 2 or 3 months, giving them the ability to find better molecules or collaborate on novel cause research earlier, as well as publishing. University mouse colony maintainers or Institutes like Wistar could create standardized cohort groups to improve research.
These researchers among others may like this video
Toshihiro Aoto, Ri-ichi Takahashi, and Masatsugu Ueda
Omer Habib, Gizem Habib, Hyun Woo Choi, Ki-Sung Hong, Jeong Tae Do, Sung-Hwan Moon Jung Kyu Choi, Gil Ah Kim, Eun Ju Lee, Seung Tae Lee, and Jeong Mook Lim Kuo-Yu Huang (a)(b), Suzanna A. de Groot , Henri Woelders, Gijsbertus T.J. van der Horst, Axel P.N. Themmen , Ben Colenbrander, J. Martje Fentener van Vlissingen Hiroyuki Arakawa, D. Caroline Blanchard, and Robert J. Blanchard Sherri E. Boucher, George R. Douglas, Iain B. Lambert, and Timothy M. Singer Kara Rosania